Title : Ccr4-not complex mRNA deadenylase activity contributes to DNA damage responses in Saccharomyces cerevisiae.

Pub. Date : 2005 Jan

PMID : 15466434






2 Functional Relationships(s)
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1 Here we show that CCR4 and CAF1, which together encode the major cytoplasmic mRNA deadenylase complex, have complex genetic interactions with the checkpoint genes DUN1, MRC1, RAD9, and RAD17 in response to DNA-damaging agents hydroxyurea (HU) and methylmethane sulfonate (MMS). Methyl Methanesulfonate chromatin-binding protein RAD9 Saccharomyces cerevisiae S288C
2 Here we show that CCR4 and CAF1, which together encode the major cytoplasmic mRNA deadenylase complex, have complex genetic interactions with the checkpoint genes DUN1, MRC1, RAD9, and RAD17 in response to DNA-damaging agents hydroxyurea (HU) and methylmethane sulfonate (MMS). Methyl Methanesulfonate chromatin-binding protein RAD9 Saccharomyces cerevisiae S288C