Pub. Date : 2004 Dec 31
PMID : 15456784
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Survivin and p53 modulate quercetin-induced cell growth inhibition and apoptosis in human lung carcinoma cells. | Quercetin | tumor protein p53 | Homo sapiens |
| 2 | However, the regulation of survivin and p53 on the quercetin-induced cell growth inhibition and apoptosis in cancer cells remains unclear. | Quercetin | tumor protein p53 | Homo sapiens |
| 3 | In this study, we investigated the roles of survivin and p53 in the quercetin-treated human lung carcinoma cells. | Quercetin | tumor protein p53 | Homo sapiens |
| 4 | Subsequently, quercetin increased the levels of total p53 (DO-1), phospho-p53 (serine 15), and p21 proteins, which were translocated to the nuclei in A549 cells. | Quercetin | tumor protein p53 | Homo sapiens |
| 5 | Subsequently, quercetin increased the levels of total p53 (DO-1), phospho-p53 (serine 15), and p21 proteins, which were translocated to the nuclei in A549 cells. | Quercetin | tumor protein p53 | Homo sapiens |
| 6 | Treatment with a specific p53 inhibitor, pifithrin-alpha, or transfection of a p53 antisense oligodeoxynucleotide enhanced the cytotoxicity of the quercetin-treated cells. | Quercetin | tumor protein p53 | Homo sapiens |
| 7 | Treatment with a specific p53 inhibitor, pifithrin-alpha, or transfection of a p53 antisense oligodeoxynucleotide enhanced the cytotoxicity of the quercetin-treated cells. | Quercetin | tumor protein p53 | Homo sapiens |
| 8 | Together, our results suggest that survivin can reduce the cell growth inhibition and apoptosis, and p53 elevates the p21 level, which may attenuate the cell death in the quercetin-treated human lung carcinoma cells. | Quercetin | tumor protein p53 | Homo sapiens |