Title : PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder.

Pub. Date : 2004 Oct 5

PMID : 15448205






1 Functional Relationships(s)
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1 Transformation in these assays, and activation of the downstream effector molecules PLC-gamma, STAT5, and phosphatidylinositol 3-kinase/AKT, required the proline-rich domains, but not the ZNF domains, of ZNF198. Proline AKT serine/threonine kinase 1 Homo sapiens