Title : Purification and reaction mechanisms of the primary inhibitor of plasmin from human plasma.

Pub. Date : 1978 Nov 1

PMID : 154322






3 Functional Relationships(s)
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1 The primary inhibitor of plasmin in human plasma was purified by a four-step procedure involving fractional (NH(4))(2)SO(4) precipitation, ion-exchange chromatography on a column of DEAE-Sepharose CL-6B and affinity chromatography on both a plasminogen-CH-Sepharose 4B column and a column of 6-aminohexanoic acid covalently coupled through the carboxylate function to AH-Sepharose 4B. Aminocaproic Acid plasminogen Homo sapiens
2 In contrast with this, the inhibitory effects of l-lysine and 6-aminohexanoic acid on the inhibitor-plasmin reaction occur at concentrations much too low to affect the active site of plasmin. Aminocaproic Acid plasminogen Homo sapiens
3 In contrast with this, the inhibitory effects of l-lysine and 6-aminohexanoic acid on the inhibitor-plasmin reaction occur at concentrations much too low to affect the active site of plasmin. Aminocaproic Acid plasminogen Homo sapiens