Pub. Date : 2004 Oct
PMID : 15385831
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Therefore, the objective of the study was to determine whether potential inhibition of CYP1A2 by the quinolone antibiotic agent ciprofloxacin would alter the stereoselective disposition of mexiletine. | Ciprofloxacin | cytochrome P450 family 1 subfamily A member 2 | Homo sapiens |
| 2 | In conclusion, the increase in mexiletine nonrenal clearance in smokers and its decrease during the combined administration of ciprofloxacin confirm the role of CYP1A2 in the overall clearance of the drug. | Ciprofloxacin | cytochrome P450 family 1 subfamily A member 2 | Homo sapiens |