Pub. Date : 2004 Oct
PMID : 15385826
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Likewise, sirolimus is a substrate for the major drug-metabolizing enzyme cytochrome P450 3A4 (CYP3A4) and the efflux transporter P-glycoprotein (P-gp), both of which are expressed in close proximity in epithelial cells lining the small intestine. | Sirolimus | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | Likewise, sirolimus is a substrate for the major drug-metabolizing enzyme cytochrome P450 3A4 (CYP3A4) and the efflux transporter P-glycoprotein (P-gp), both of which are expressed in close proximity in epithelial cells lining the small intestine. | Sirolimus | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | Modified Caco-2 cells metabolized [14C]sirolimus to the same CYP3A4-mediated metabolites as human small intestinal and liver microsomes. | Sirolimus | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | Along with CYP3A4-mediated metabolism and P-gp-mediated efflux, a novel elimination pathway was identified that may also contribute to the first-pass extraction, and hence low oral bioavailability, of sirolimus. | Sirolimus | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |