Title : Interleukin 1beta inhibits CAR-induced expression of hepatic genes involved in drug and bilirubin clearance.

Pub. Date : 2004 Oct

PMID : 15382119






1 Functional Relationships(s)
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1 We show that IL-1beta decreases CAR expression and decreases phenobarbital- or bilirubin-mediated induction of CYP2B6, CYP2C9, CYP3A4, UGT1A1, GSTA1, GSTA2, and SLC21A6 messenger RNA. Phenobarbital UDP glucuronosyltransferase family 1 member A1 Homo sapiens