Pub. Date : 2004 Oct
PMID : 15377640
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The objectives of this study were to characterize and compare the reversible inhibition and time-dependent inactivation of cytochromes P450 3A4 and 3A5 (CYP3A4 and CYP3A5) by erythromycin, diltiazem, and nicardipine. | Diltiazem | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 2 | In conclusion, erythromycin, diltiazem, and nicardipine were weaker inhibitors of CYP3A5 and inactivated the enzyme at a slower rate than their respective effects on CYP3A4. | Diltiazem | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |