Title : 15-Deoxy-Delta12,14-prostaglandin J2 and thiazolidinediones transactivate epidermal growth factor and platelet-derived growth factor receptors in vascular smooth muscle cells.

Pub. Date : 2004 Oct 15

PMID : 15369766






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Stimulation of VSMCs with 15-d-PGJ2 or TZDs for 15 min induced phosphorylation of ERK1/2 and Akt. Thiazolidinediones AKT serine/threonine kinase 1 Homo sapiens
2 15-d-PGJ2- or TZDs-induced phosphorylation of ERK1/2 and Akt was inhibited by AG1478, an inhibitor of epidermal growth factor receptor (EGF-R) as well as AG1295, an inhibitor of platelet derived growth factor receptor (PDGF-R). Thiazolidinediones AKT serine/threonine kinase 1 Homo sapiens
3 GM6001, a matrix metalloproteinase inhibitor, and PP2, a Src family protein kinase inhibitor, suppressed 15-d-PGJ2- and TZDs-induced phosphorylation of EGF-R and PDGFbeta-R as well as activation of ERK1/2 and Akt. Thiazolidinediones AKT serine/threonine kinase 1 Homo sapiens