Title : Profile of resistance of human immunodeficiency virus to mannose-specific plant lectins.

Pub. Date : 2004 Oct

PMID : 15367629






1 Functional Relationships(s)
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1 The nature of these mutations was entirely different from that of mutations that are known to appear in HIV-1 gp120 under the pressure of other viral entry inhibitors such as dextran sulfate, bicyclams (i.e., AMD3100), and chicoric acid, which also explains the lack of cross-resistance of plant lectin-resistant viruses to any other HIV inhibitor including T-20 and the blue-green algae (cyanobacteria)-derived mannose-specific cyanovirin. Mannose Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1