Title : Reduced PTEN expression in breast cancer cells confers susceptibility to inhibitors of the PI3 kinase/Akt pathway.

Pub. Date : 2004 Oct

PMID : 15367412






1 Functional Relationships(s)
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1 These findings indicate that inhibitors of mTOR, some of which are already in clinical development (CCI-779, an ester of rapamycin), have the potential to be effective in the treatment of breast cancer patients with PTEN-negative tumors and should be evaluated in this setting. Esters mechanistic target of rapamycin kinase Homo sapiens