Pub. Date : 2004 Oct
PMID : 15365094
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mechanism of block of hEag1 K+ channels by imipramine and astemizole. | Imipramine | potassium voltage-gated channel subfamily H member 1 | Homo sapiens |
| 2 | The tricyclic antidepressant imipramine and the antihistamine astemizole inhibit the current through Eag1 channels and reduce the proliferation of cancer cells. | Imipramine | potassium voltage-gated channel subfamily H member 1 | Homo sapiens |
| 3 | Even if both drugs differ in their affinity for hEag1 channels (IC50s are approximately 2 microM for imipramine and approximately 200 nM for astemizole) and in their blocking kinetics, both drugs permeate the membrane and inhibit the hEag1 current by selectively binding to open channels. | Imipramine | potassium voltage-gated channel subfamily H member 1 | Homo sapiens |