Title : Optimal lysophosphatidic acid-induced DNA synthesis and cell migration but not survival require intact autophosphorylation sites of the epidermal growth factor receptor.

Pub. Date : 2004 Nov 12

PMID : 15364923






8 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Optimal lysophosphatidic acid-induced DNA synthesis and cell migration but not survival require intact autophosphorylation sites of the epidermal growth factor receptor. lysophosphatidic acid epidermal growth factor receptor Homo sapiens
2 In contrast, LPA-elicited DNA synthesis and migration were augmented in cells expressing EGFR, EGFR(K721A), or EGFR(Y845F), but not EGFR(Y5F), although the PDGF responses were indistinguishable. lysophosphatidic acid epidermal growth factor receptor Homo sapiens
3 In contrast, LPA-elicited DNA synthesis and migration were augmented in cells expressing EGFR, EGFR(K721A), or EGFR(Y845F), but not EGFR(Y5F), although the PDGF responses were indistinguishable. lysophosphatidic acid epidermal growth factor receptor Homo sapiens
4 In contrast, LPA-elicited DNA synthesis and migration were augmented in cells expressing EGFR, EGFR(K721A), or EGFR(Y845F), but not EGFR(Y5F), although the PDGF responses were indistinguishable. lysophosphatidic acid epidermal growth factor receptor Homo sapiens
5 In contrast, LPA-elicited DNA synthesis and migration were augmented in cells expressing EGFR, EGFR(K721A), or EGFR(Y845F), but not EGFR(Y5F), although the PDGF responses were indistinguishable. lysophosphatidic acid epidermal growth factor receptor Homo sapiens
6 LPA-induced transphosphorylation of the EGFR, ErbB2, or PDGF receptor was not required for its antiapoptotic effect. lysophosphatidic acid epidermal growth factor receptor Homo sapiens
7 In EGFR(Y5F)-expressing cells, LPA failed to elicit tyrosine phosphorylation of Src homologous and collagen protein (SHC) and caused only a modest increase in ERK1/2 phosphorylation similar to that in wild-type B82L cells. lysophosphatidic acid epidermal growth factor receptor Homo sapiens
8 The present data pinpoint the lack of importance of the intrinsic kinase activity in contrast to the importance of autophosphorylation sites of the EGFR for SHC phosphorylation in the enhancement of select ERK1/2-dependent LPA responses. lysophosphatidic acid epidermal growth factor receptor Homo sapiens