Pub. Date : 2004 Sep 13
PMID : 15363974
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We now evaluated the anti-inflammatory mechanisms of andrographolide on complement 5a (C5a)-induced macrophage recruitment in vitro. | andrographolide | complement C5a receptor 1 | Homo sapiens |
| 2 | Andrographolide significantly attenuated C5a-stimulated phosphorylation of ERK1/2, and of its upstream activator, MAP kinase-ERK kinase (MEK1/2). | andrographolide | complement C5a receptor 1 | Homo sapiens |
| 3 | C5a-activated ERK1/2 phosphorylation was 86+/-9% inhibited by 30 microM andrographolide. | andrographolide | complement C5a receptor 1 | Homo sapiens |
| 4 | Andrographolide also strongly abolished C5a-stimulated Akt phosphorylation, a downstream target protein for PI3K. | andrographolide | complement C5a receptor 1 | Homo sapiens |