Pub. Date : 2004 Dec
PMID : 15358633
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | n-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the COX-2/PGE2 induced ERK-1 and -2 and HIF-1alpha induction pathway. | Dinoprostone | vascular endothelial growth factor A | Homo sapiens |
| 2 | Moreover, they inhibited ERK-1 and -2 phosphorylation and HIF-1alpha protein over-expression, critical steps in the PGE(2)-induced signaling pathway leading to the augmented expression of VEGF in colon cancer cells. | Dinoprostone | vascular endothelial growth factor A | Homo sapiens |