Title : Regulation of the membrane-localized prostaglandin E synthases mPGES-1 and mPGES-2 in cardiac myocytes and fibroblasts.

Pub. Date : 2005 Jan

PMID : 15358613






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The proinflammatory mediator cyclooxygenase (COX)-2 and its product PGE(2) are induced in the ischemic heart, contributing to inflammatory cell infiltration, fibroblast proliferation, and cardiac hypertrophy. Prostaglandins E mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 PGE(2) synthesis coupled to COX-2 involves two membrane-localized PGE synthases, mPGES-1 and mPGES-2; however, it is not clear how these synthases are regulated in cardiac myocytes and fibroblasts. Prostaglandins E mitochondrially encoded cytochrome c oxidase II Homo sapiens