Pub. Date : 2005 Jan
PMID : 15358613
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The proinflammatory mediator cyclooxygenase (COX)-2 and its product PGE(2) are induced in the ischemic heart, contributing to inflammatory cell infiltration, fibroblast proliferation, and cardiac hypertrophy. | Prostaglandins E | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 2 | PGE(2) synthesis coupled to COX-2 involves two membrane-localized PGE synthases, mPGES-1 and mPGES-2; however, it is not clear how these synthases are regulated in cardiac myocytes and fibroblasts. | Prostaglandins E | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |