Title : A lipid peroxidation-derived inflammatory mediator: identification of 4-hydroxy-2-nonenal as a potential inducer of cyclooxygenase-2 in macrophages.

Pub. Date : 2004 Nov 12

PMID : 15355999






1 Functional Relationships(s)
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1 COX-2 was found to colocalize with 4-hydroxy-2-nonenal (HNE), a major lipid peroxidation-derived aldehyde, in foamy macrophages within human atheromatous lesions, suggesting that COX-2 expression may be associated with the accumulation of lipid peroxidation products within macrophages. Aldehydes mitochondrially encoded cytochrome c oxidase II Homo sapiens