Pub. Date : 2005 Jan
PMID : 15355849
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Depletion of cellular polyamines by pretreatment with alpha-difluoromethylornithine (DFMO) prevented increases in c-myc expression and DNA synthesis induced by 5% dFBS. | Eflornithine | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 2 | Depletion of cellular polyamines by pretreatment with alpha-difluoromethylornithine (DFMO) prevented increases in c-myc expression and DNA synthesis induced by 5% dFBS. | Eflornithine | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 3 | c-Myc gene transcription and cell proliferation decreased in polyamine-deficient cells, whereas the natural polyamine spermidine given together with DFMO maintained c-myc gene expression and cell growth at normal levels. | Eflornithine | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 4 | Disruption of c-myc expression using specific c-myc antisense oligomers not only inhibited normal cell growth (without DFMO) but also prevented the restoration of cell proliferation by spermidine in polyamine-deficient cells. | Eflornithine | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |