Title : Polymorphisms in the hypoxia inducible factor-1alpha gene (HIF1A) are associated with the renal cell carcinoma phenotype.

Pub. Date : 2004 Sep

PMID : 15350301






1 Functional Relationships(s)
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1 These polymorphisms are found within the oxygen-dependent degradation domain of the HIF-1alpha protein and may be important in the oxygen regulation of the protein via hydroxylation of the proline residue at position 564 (P564) by HIF-alpha prolyl hydroxylase (HIF-PH). Proline hypoxia inducible factor 1 subunit alpha Homo sapiens