Title : Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis.

Pub. Date : 2004 Sep

PMID : 15343391






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The epidermis of Stat3-deficient mice showed a significantly reduced proliferative response following treatment with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) because of a defect in G1-to-S-phase cell cycle progression. Tetradecanoylphorbol Acetate signal transducer and activator of transcription 3 Mus musculus
2 The epidermis of Stat3-deficient mice showed a significantly reduced proliferative response following treatment with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) because of a defect in G1-to-S-phase cell cycle progression. Tetradecanoylphorbol Acetate signal transducer and activator of transcription 3 Mus musculus
3 Notably, Stat3-deficient mice were completely resistant to skin tumor development when DMBA was used as the initiator and TPA as the promoter. Tetradecanoylphorbol Acetate signal transducer and activator of transcription 3 Mus musculus