Title : Simultaneous changes in various mechanisms that mediate the cell incorporation of folate compounds account for low levels of resistance to methotrexate.

Pub. Date : 1992 Mar

PMID : 1533575






1 Functional Relationships(s)
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1 The increase of the mFBP expression, besides ensuring the growth of resistant cells by its contribution to the reduced folate intake, also participates in the methotrexate resistance by the internalization of folate cofactor which would compete with methotrexate hindering the effective inhibition of dihydrofolate reductase by the antifolate. Folic Acid far upstream element (FUSE) binding protein 1 Mus musculus