Title : Identification of critical amino acid residues of human CYP2A13 for the metabolic activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco-specific carcinogen.

Pub. Date : 2004 Dec

PMID : 15333516






1 Functional Relationships(s)
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1 The role of these amino acid residues in CYP2A13-catalyzed reactions is clearly substrate-dependent, since the same Ala117Val and His372Arg mutants showed a 9-fold increase in the catalytic efficiency for coumarin 7-hydroxylation. coumarin cytochrome P450 family 2 subfamily A member 13 Homo sapiens