Title : Small interfering RNA-mediated suppression of dUTPase sensitizes cancer cell lines to thymidylate synthase inhibition.

Pub. Date : 2004 Sep

PMID : 15322254






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1 To validate the potential of dUTPase as a target for drug development, we used small interfering RNA directed against this enzyme and determined the effects of decreasing levels of dUTPase on sensitivity to the thymidylate synthase (TS) inhibitor fluorodeoxyuridine (FUdR) in human cancer cell lines. Floxuridine Deoxyuridine triphosphatase Drosophila melanogaster