Title : YC-1-induced cyclooxygenase-2 expression is mediated by cGMP-dependent activations of Ras, phosphoinositide-3-OH-kinase, Akt, and nuclear factor-kappaB in human pulmonary epithelial cells.

Pub. Date : 2004 Sep

PMID : 15322248






2 Functional Relationships(s)
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1 We demonstrated previously that 3-(5"-hydroxymethyl-2"-furyl)-1-benzylindazole (YC-1), an activator of soluble guanylate cyclase (sGC), induces cyclooxygenase-2 (COX-2) expression via cGMP- and p44/42 mitogen-activated protein kinase-dependent pathways in human pulmonary epithelial A549 cells. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole prostaglandin-endoperoxide synthase 2 Homo sapiens
2 We demonstrated previously that 3-(5"-hydroxymethyl-2"-furyl)-1-benzylindazole (YC-1), an activator of soluble guanylate cyclase (sGC), induces cyclooxygenase-2 (COX-2) expression via cGMP- and p44/42 mitogen-activated protein kinase-dependent pathways in human pulmonary epithelial A549 cells. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole prostaglandin-endoperoxide synthase 2 Homo sapiens