Title : COX-2 Regulates the insulin-like growth factor I-induced potentiation of Zn(2+)-toxicity in primary cortical culture.

Pub. Date : 2004 Sep

PMID : 15322227






1 Functional Relationships(s)
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1 These results suggest that COX-2 is an endogenous factor responsible for the IGF-I-induced potentiation of Zn(2+) toxicity and that enhanced COX-2 activity leads to a decrease in the cell"s reducing power and an increase in ROS accumulation in primary cortical cultures. Reactive Oxygen Species mitochondrially encoded cytochrome c oxidase II Homo sapiens