Title : Up-regulation of basal transcriptional activity of the cytochrome P450 cholesterol side-chain cleavage (CYP11A) gene by isoform-specific calcium-calmodulin-dependent protein kinase in primary cultures of ovarian granulosa cells.

Pub. Date : 2004 Dec

PMID : 15319355






2 Functional Relationships(s)
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1 Forskolin, an activator of adenylyl cyclase, stimulated expression of CYP11A/luciferase by 4.5 +/- 0.9-fold (P < 0.001) and did not enhance transcriptional drive by exogenous CamKIV. Colforsin cytochrome P450 family 11 subfamily A member 1 Homo sapiens
2 The dominant-negative mutant of the cAMP-responsive element binding protein also repressed forskolin"s stimulation of -100/+23 CYP11A/luciferase by 12, 38, and 52% (P < 0.01). Colforsin cytochrome P450 family 11 subfamily A member 1 Homo sapiens