Pub. Date : 2004 Sep
PMID : 15319341
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CYP3A4 was found to play a major role in etoposide metabolism (K(m) = 77.7 +/- 27.8 microM; V(max) = 314 +/- 84 pmol of catechol/min/nmol of P450). | Etoposide | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | Etoposide (40, 5, 1, and 0.25 microM) caused a slight increase in CYP3A4 mRNA in three of five batches of hepatocytes but did not result in proportionately increased CYP3A4 protein levels. | Etoposide | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |