Pub. Date : 2004 Aug 15
PMID : 15313912
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | LPA, which is constitutively produced by ovarian cancer cells, induced HB-EGF ectodomain shedding in SKOV3 and RMG-1 cells, resulting in the transactivation of EGFR and the downstream kinase extracellular signal-regulated kinase/mitogen-activated protein kinase. | lysophosphatidic acid | epidermal growth factor receptor | Homo sapiens |
| 2 | Introduction of lipid phosphate phosphohydrolase, which hydrolyzes LPA, decreased the constitutive shedding of HB-EGF, EGFR transactivation, and the tumorigenic potential of SKOV3 and RMG-1 cells. | lysophosphatidic acid | epidermal growth factor receptor | Homo sapiens |
| 3 | These results indicate that HB-EGF is the primary member of the EGFR family of growth factors expressed in ovarian cancer and that LPA-induced ectodomain shedding of this growth factor is a critical step in tumor formation, making HB-EGF a novel therapeutic target for ovarian cancer. | lysophosphatidic acid | epidermal growth factor receptor | Homo sapiens |