Title : A miniprotein scaffold used to assemble the polyproline II binding epitope recognized by SH3 domains.

Pub. Date : 2004 Sep 3

PMID : 15313630






1 Functional Relationships(s)
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1 Furthermore, the mutation by Tyr of two proline residues in APP-RP1, which are essential for the binding of some linear peptides to Abl-SH3, demonstrates the effectiveness of the scaffold in enhancing the variability in the design of high-affinity and high-specificity ligands for any SH3 domain. Proline ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens