Title : Cytochrome P450 3A4 is the major enzyme involved in the metabolism of the substance P receptor antagonist aprepitant.

Pub. Date : 2004 Nov

PMID : 15304427






1 Functional Relationships(s)
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1 Aprepitant was a moderate inhibitor of CYP3A4, with Ki values of approximately 10 microM for the 1"- and 4-hydroxylation of midazolam, and the N-demethylation of diltiazem, respectively. Diltiazem cytochrome P450 family 3 subfamily A member 4 Homo sapiens