Title : Hepatobiliary disposition of the metabolically stable opioid peptide [D-Pen2, D-Pen5]-enkephalin (DPDPE): pharmacokinetic consequences of the interplay between multiple transport systems.

Pub. Date : 2004 Dec

PMID : 15302892






2 Functional Relationships(s)
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1 The present studies determined the relative impact of Mrp2 and P-gp on the hepatobiliary disposition of [3H]DPDPE in isolated perfused rat livers (IPLs). Tritium ATP binding cassette subfamily C member 2 Rattus norvegicus
2 Mrp2 is the primary mechanism for [3H]DPDPE biliary excretion, and P-gp facilitates excretion of [3H]DPDPE only in the absence of functional Mrp2. Tritium ATP binding cassette subfamily C member 2 Rattus norvegicus