Title : Ectopic expression of URA3 can influence the virulence phenotypes and proteome of Candida albicans but can be overcome by targeted reintegration of URA3 at the RPS10 locus.

Pub. Date : 2004 Aug

PMID : 15302823






1 Functional Relationships(s)
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1 Uridine auxotrophy, based on disruption of both URA3 alleles in diploid Candida albicans strain SC5314, has been widely used to select gene deletion mutants created in this fungus by "Ura-blasting" and PCR-mediated disruption. Uridine orotidine-5'-phosphate decarboxylase Candida albicans SC5314