Title : TIS21/BTG2/PC3 is expressed through PKC-delta pathway and inhibits binding of cyclin B1-Cdc2 and its activity, independent of p53 expression.

Pub. Date : 2004 Sep 10

PMID : 15302583






2 Functional Relationships(s)
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1 In summary, TPA-induced TIS21 mRNA expression is mediated by PKC-delta, and TIS21 induces G2/M arrest and cell death by inhibiting cyclin B1-Cdc2 binding and the kinase activity through its binding to Cdc2. Tetradecanoylphorbol Acetate cyclin dependent kinase 1 Homo sapiens
2 In summary, TPA-induced TIS21 mRNA expression is mediated by PKC-delta, and TIS21 induces G2/M arrest and cell death by inhibiting cyclin B1-Cdc2 binding and the kinase activity through its binding to Cdc2. Tetradecanoylphorbol Acetate cyclin dependent kinase 1 Homo sapiens