Pub. Date : 2004 Aug
PMID : 15302288
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVE: To assess and compare the effect of conjugated estrogen and of the selective estrogen receptor modulator raloxifene on serum levels of insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) and on the IGF-I/IGFBP-3 ratio. | Raloxifene Hydrochloride | insulin like growth factor 1 | Homo sapiens |
| 2 | OBJECTIVE: To assess and compare the effect of conjugated estrogen and of the selective estrogen receptor modulator raloxifene on serum levels of insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) and on the IGF-I/IGFBP-3 ratio. | Raloxifene Hydrochloride | insulin like growth factor 1 | Homo sapiens |
| 3 | RESULT(S): Both raloxifene and CEE decreased serum IGF-I concentration. | Raloxifene Hydrochloride | insulin like growth factor 1 | Homo sapiens |
| 4 | Compared with placebo, the decrease in IGF-I/IGFBP-3 ratio was -32.5% (95% CI: -20.1; -44.8%) for CEE; -16.4% (95% CI: -3.6; -29.2%) for raloxifene at 150 mg/day; and -15.4% (95% CI: -1.0; -29.8%) for raloxifene at 60 mg/day. | Raloxifene Hydrochloride | insulin like growth factor 1 | Homo sapiens |
| 5 | Compared with placebo, the decrease in IGF-I/IGFBP-3 ratio was -32.5% (95% CI: -20.1; -44.8%) for CEE; -16.4% (95% CI: -3.6; -29.2%) for raloxifene at 150 mg/day; and -15.4% (95% CI: -1.0; -29.8%) for raloxifene at 60 mg/day. | Raloxifene Hydrochloride | insulin like growth factor 1 | Homo sapiens |
| 6 | CONCLUSION(S): Long-term use of both CEE and raloxifene decreases serum IGF-I and the IGF-I/IGFBP-3 ratio, but, unlike CEE, raloxifene produced a significant yet small increase in IGFBP-3. | Raloxifene Hydrochloride | insulin like growth factor 1 | Homo sapiens |
| 7 | CONCLUSION(S): Long-term use of both CEE and raloxifene decreases serum IGF-I and the IGF-I/IGFBP-3 ratio, but, unlike CEE, raloxifene produced a significant yet small increase in IGFBP-3. | Raloxifene Hydrochloride | insulin like growth factor 1 | Homo sapiens |