Title : Connective tissue growth factor expression and induction by transforming growth factor-beta is abrogated by simvastatin via a Rho signaling mechanism.

Pub. Date : 2004 Dec

PMID : 15298857






3 Functional Relationships(s)
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1 Signaling pathways driving simvastatin"s effects on CTGF/TGF-beta interaction were evaluated using transient reporter transfection of a CTGF promoter construct. Simvastatin transforming growth factor beta 1 Homo sapiens
2 Inhibition of CTGF promoter activity by simvastatin was most marked at 10 muM concentration, reducing activity by 76.2 and 51.8% over TGF-beta-stimulated cultures in IPF and normal fibroblasts, respectively. Simvastatin transforming growth factor beta 1 Homo sapiens
3 Indeed, the specific Rho inhibitor C3 exotoxin significantly (P < 0.05) suppressed TGF-beta-induced CTGF promoter activity in transfected lung fibroblasts, a finding further supported by transfection of dominant-negative and constitutively active RhoA constructs, thus demonstrating that simvastatin through a Rho signaling mechanism in lung fibroblasts can modulate CTGF expression and interaction with TGF-beta. Simvastatin transforming growth factor beta 1 Homo sapiens