Pub. Date : 2004 Dec
PMID : 15292462
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | N-glucuronidation of carbamazepine in human tissues is mediated by UGT2B7. | Carbamazepine | UDP glucuronosyltransferase family 2 member B7 | Homo sapiens |
| 2 | We have developed a sensitive liquid chromatography/mass spectrometry assay to quantify CBZ glucuronidation, and we report that CBZ is specifically glucuronidated by human UGT2B7. | Carbamazepine | UDP glucuronosyltransferase family 2 member B7 | Homo sapiens |
| 3 | We have developed a sensitive liquid chromatography/mass spectrometry assay to quantify CBZ glucuronidation, and we report that CBZ is specifically glucuronidated by human UGT2B7. | Carbamazepine | UDP glucuronosyltransferase family 2 member B7 | Homo sapiens |
| 4 | Kinetics of CBZ glucuronidation in human liver, kidney, and intestine microsomes were consistent with those of recombinant UGT2B7, which displayed a Km value of 214 microM and Vmax value of 0.79 pmol/mg/min. | Carbamazepine | UDP glucuronosyltransferase family 2 member B7 | Homo sapiens |
| 5 | In addition to revealing the isoform responsible for CBZ glucuronidation, this is the first example of primary amine glucuronidation by UGT2B7. | Carbamazepine | UDP glucuronosyltransferase family 2 member B7 | Homo sapiens |