Pub. Date : 2004 Sep 24
PMID : 15280372
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Protein kinase Cdelta mediates lysophosphatidic acid-induced NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells. | lysophosphatidic acid | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | Here, we report that protein kinase Cdelta (PKCdelta) mediates LPA-induced NF-kappaB transcription and interleukin-8 (IL-8) secretion in HBEpCs. | lysophosphatidic acid | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | LPA caused a marked activation of NF-kappaB in HBEpCs as determined by IkappaB phosphorylation and of NF-kappaB nuclear translocation and a strong induction of NF-kappaB promoter-mediated luciferase activity. | lysophosphatidic acid | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | LPA caused a marked activation of NF-kappaB in HBEpCs as determined by IkappaB phosphorylation and of NF-kappaB nuclear translocation and a strong induction of NF-kappaB promoter-mediated luciferase activity. | lysophosphatidic acid | nuclear factor kappa B subunit 1 | Homo sapiens |
| 5 | LPA caused a marked activation of NF-kappaB in HBEpCs as determined by IkappaB phosphorylation and of NF-kappaB nuclear translocation and a strong induction of NF-kappaB promoter-mediated luciferase activity. | lysophosphatidic acid | nuclear factor kappa B subunit 1 | Homo sapiens |
| 6 | Furthermore, LPA-activated PKCdelta and the LPA-mediated activation of NF-kappaB and IL-8 production were attenuated by overexpression of dominant-negative PKCdelta and rottlerin. | lysophosphatidic acid | nuclear factor kappa B subunit 1 | Homo sapiens |
| 7 | These results demonstrate for the first time that LPA is a potent stimulator of IL-8 production in HBEpCs, which involves PKCdelta/NF-kappaB signaling pathways. | lysophosphatidic acid | nuclear factor kappa B subunit 1 | Homo sapiens |