Title : COX-2 selective inhibitors, carbonic anhydrase inhibition and anticancer properties of sulfonamides belonging to this class of pharmacological agents.

Pub. Date : 2004 Aug

PMID : 15279596






1 Functional Relationships(s)
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1 It was recently shown that the sulfonamide COX-2 selective inhibitors (but not the methylsulfone ones) also act as nanomolar inhibitors of several isozymes of the metallo-enzyme carbonic anhydrase (CA), some of which are strongly involved in tumourigenesis. Sulfonamides mitochondrially encoded cytochrome c oxidase II Homo sapiens