Pub. Date : 2004 Sep 24
PMID : 15262979
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here we report a potential regulatory role of caspase-2 on caspase-8 during ceramide-induced apoptosis. | Ceramides | caspase 8 | Homo sapiens |
| 2 | Ceramide-induced caspase-8 activation, mitochondrial damage, and apoptosis were blocked in caspase-2 short interfering RNA-expressing cells. | Ceramides | caspase 8 | Homo sapiens |
| 3 | Therefore, caspase-2 acts upstream of caspase-8 during ceramide-induced mitochondrial apoptosis. | Ceramides | caspase 8 | Homo sapiens |
| 4 | These data suggest sequential initiator caspase-2 and caspase-8 activation in the mitochondrial apoptotic pathway induced by ceramide or etoposide. | Ceramides | caspase 8 | Homo sapiens |