Pub. Date : 2004 Aug
PMID : 15254726
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Expression profiles of p53, p21, bax and bcl-2 proteins in all-trans-retinoic acid treated primary and metastatic melanoma cells. | Tretinoin | BCL2 apoptosis regulator | Homo sapiens |
| 2 | In this study, we used a similar cell culture model system of matched primary and metastatic melanoma cells from the same patient to investigate whether p53 and bcl-2 family proteins were involved in atRA-induced apoptosis. | Tretinoin | BCL2 apoptosis regulator | Homo sapiens |
| 3 | Expression of p53, p21 and bax was increased, and bcl-2 was decreased in melanoma cells after exposure to atRA at different concentrations for various periods of time. | Tretinoin | BCL2 apoptosis regulator | Homo sapiens |
| 4 | These data indicate that p53, p21, bax and bcl-2 proteins were involved in atRA-induced apoptosis in melanoma cells. | Tretinoin | BCL2 apoptosis regulator | Homo sapiens |