Title : Cytochrome P450 pharmacogenetics as a predictor of toxicity and clinical response to pulse cyclophosphamide in lupus nephritis.

Pub. Date : 2004 Jul

PMID : 15248218






1 Functional Relationships(s)
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1 Patients who were either heterozygous or homozygous for CYP2C19*2 had a significantly lower risk of developing premature ovarian failure (relative risk 0.10; 95% confidence interval 0.02-0.52), after adjustment for age and total number of cyclophosphamide pulses received. Cyclophosphamide cytochrome P450 family 2 subfamily C member 19 Homo sapiens