Title : Nitric-oxide-donating NSAIDs as agents for cancer prevention.

Pub. Date : 2004 Jul

PMID : 15242680






1 Functional Relationships(s)
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1 Mechanistically, NO-aspirin, the best-studied NO-NSAID, has pleiotropic effects on cell signaling (it inhibits Wnt signaling, induces nitric oxide synthase and NF-kappaB activation and induces cyclooxygenase-2 expression), and this mechanistic redundancy might be central to its mode of action against cancer. Aspirin prostaglandin-endoperoxide synthase 2 Homo sapiens