Title : AMPK activation may suppress hepatic production of C-reactive protein by stimulating nitric oxide synthase.

Pub. Date : 2004

PMID : 15236798






3 Functional Relationships(s)
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1 Strategies for decreasing elevated CRP include administration of statins, thiazolidinediones, and metformin; moderate alcohol consumption and appropriate weight loss are also helpful in this regard. Metformin C-reactive protein Homo sapiens
2 Thus, it is proposed that metformin--or AMPK---inhibits hepatic CRP production by boosting hepatic nitric oxide synthesis, which in turn impedes Stat3 activation and CRP transcription. Metformin C-reactive protein Homo sapiens
3 Thus, it is proposed that metformin--or AMPK---inhibits hepatic CRP production by boosting hepatic nitric oxide synthesis, which in turn impedes Stat3 activation and CRP transcription. Metformin C-reactive protein Homo sapiens