Title : [Effect of arsenic trioxide on telomerase and telomerase reverse transcriptase in KM3 cell line].

Pub. Date : 2004 Jun

PMID : 15228664






3 Functional Relationships(s)
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1 The results showed that arsenic trioxide inhibited the growth and viability of KM(3) cell and induced apoptosis; cell cycle was arrested in G(2) phase; arsenic trioxide could inhibit telomerase activity, which consisted with the downtrend of hTERT mRNA expression. Arsenic Trioxide telomerase reverse transcriptase Homo sapiens
2 The results showed that arsenic trioxide inhibited the growth and viability of KM(3) cell and induced apoptosis; cell cycle was arrested in G(2) phase; arsenic trioxide could inhibit telomerase activity, which consisted with the downtrend of hTERT mRNA expression. Arsenic Trioxide telomerase reverse transcriptase Homo sapiens
3 In conclusion, down-regulation of telomerase activity and hTERT may play an important role in the apoptosis of MM cell line KM(3) induced by arsenic trioxide. Arsenic Trioxide telomerase reverse transcriptase Homo sapiens