Pub. Date : 2004 Jul
PMID : 15225321
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We have isolated PAS-resistant transposon mutants of Mycobacterium bovis BCG with insertions in the thymidylate synthase (thyA) gene, a critical determinant of intracellular folate levels. | Folic Acid | thymidylate synthetase | Homo sapiens |
| 2 | We have isolated PAS-resistant transposon mutants of Mycobacterium bovis BCG with insertions in the thymidylate synthase (thyA) gene, a critical determinant of intracellular folate levels. | Folic Acid | thymidylate synthetase | Homo sapiens |
| 3 | BCG thyA mutants have reduced thymidylate synthase activity and are resistant to known inhibitors of the folate pathway. | Folic Acid | thymidylate synthetase | Homo sapiens |
| 4 | Thus, PAS acts in the folate pathway, and thyA mutations probably represent a mechanism of developing resistance not only to PAS but also to other drugs that target folate metabolism. | Folic Acid | thymidylate synthetase | Homo sapiens |