Title : Structural basis for competitive inhibition of eIF4G-Mnk1 interaction by the adenovirus 100-kilodalton protein.

Pub. Date : 2004 Jul

PMID : 15220445






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Cap-dependent mRNA translation generally correlates with Mnk1 phosphorylation of eIF4E when both are bound to eIF4G. cap eukaryotic translation initiation factor 4 gamma 1 Homo sapiens
2 The eIF4G-binding site is located in an N-terminal 66-amino-acid peptide of 100K which is sufficient to bind eIF4G, displace Mnk1, block eIF4E phosphorylation, and inhibit eIF4F (cap)-dependent cellular mRNA translation. cap eukaryotic translation initiation factor 4 gamma 1 Homo sapiens
3 The eIF4G-binding site is located in an N-terminal 66-amino-acid peptide of 100K which is sufficient to bind eIF4G, displace Mnk1, block eIF4E phosphorylation, and inhibit eIF4F (cap)-dependent cellular mRNA translation. cap eukaryotic translation initiation factor 4 gamma 1 Homo sapiens