Pub. Date : 2004 May-Jun
PMID : 15211619
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Statistically significant increases in mRNA expressions, protein concentrations and catalytic activities of CYP1A1 were observed in animals exposed to BaP, to BaP coated onto (56)Fe(2)O(3) particles or to BaP coated onto (54)Fe(2)O(3) particles versus controls. | Benzo(a)pyrene | cytochrome P450, family 1, subfamily a, polypeptide 1 | Rattus norvegicus |
| 2 | Statistically significant increases in mRNA expressions, protein concentrations and catalytic activities of CYP1A1 were observed in animals exposed to BaP, to BaP coated onto (56)Fe(2)O(3) particles or to BaP coated onto (54)Fe(2)O(3) particles versus controls. | Benzo(a)pyrene | cytochrome P450, family 1, subfamily a, polypeptide 1 | Rattus norvegicus |
| 3 | Statistically significant increases in mRNA expressions, protein concentrations and catalytic activities of CYP1A1 were observed in animals exposed to BaP, to BaP coated onto (56)Fe(2)O(3) particles or to BaP coated onto (54)Fe(2)O(3) particles versus controls. | Benzo(a)pyrene | cytochrome P450, family 1, subfamily a, polypeptide 1 | Rattus norvegicus |
| 4 | Both of the BaP/Fe(2)O(3) mixtures induced higher CYP1A1 protein levels and EROD activities than BaP alone. | Benzo(a)pyrene | cytochrome P450, family 1, subfamily a, polypeptide 1 | Rattus norvegicus |
| 5 | Iron oxide particles per se did not affect mRNA levels of cyp1a1 but only enhanced BaP-mediated increases of CYP1A1 protein levels and activity. | Benzo(a)pyrene | cytochrome P450, family 1, subfamily a, polypeptide 1 | Rattus norvegicus |
| 6 | Taken together, these novel data support the hypothesis that the Fe(2)O(3)-induced increases of the metabolic activation of BaP might rely on the property of Fe(2)O(3) particles to enhance the BaP-induced translation rate of the cyp1a1 gene into functional haemoproteins. | Benzo(a)pyrene | cytochrome P450, family 1, subfamily a, polypeptide 1 | Rattus norvegicus |
| 7 | Taken together, these novel data support the hypothesis that the Fe(2)O(3)-induced increases of the metabolic activation of BaP might rely on the property of Fe(2)O(3) particles to enhance the BaP-induced translation rate of the cyp1a1 gene into functional haemoproteins. | Benzo(a)pyrene | cytochrome P450, family 1, subfamily a, polypeptide 1 | Rattus norvegicus |