Pub. Date : 2004 Jun 15
PMID : 15208028
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Interestingly SK2 V342G became CTX sensitive with a Kd of 19 nM and was also KTX sensitive Kd=97 nM. | ktx | potassium calcium-activated channel subfamily N member 2 | Homo sapiens |
| 2 | SK2 S344E (KdCTX = 105 nM,KdKTX = 144 nM) and G348D (KdCTX = 31 nM,Kd KTX = 89 nM) became also CTX and KTX sensitive with a lower affinity. | ktx | potassium calcium-activated channel subfamily N member 2 | Homo sapiens |
| 3 | Because the exchange of a single residue could create a new high affinity binding site for CTX and KTX we concluded that the outer vestibule around position V342, S344, and G348 of the SK2 K+ channel pore is very similar to those of voltage-gated K+ channels such as the Shaker K+ channel, Kv1.1 and Kv1.3 channels and also to the prokaryotic KcsA channel. | ktx | potassium calcium-activated channel subfamily N member 2 | Homo sapiens |
| 4 | Interestingly SK2 V342G became CTX sensitive with a Kd of 19 nM and was also KTX sensitive Kd = 97 nM. | ktx | potassium calcium-activated channel subfamily N member 2 | Homo sapiens |
| 5 | SK2 S344E (KdCTX = 105 nM,KdKTX = 144 nM) and G348D (KdCTX = 31 nM,Kd KTX = 89 nM) became also CTX and KTX sensitive with a lower affinity. | ktx | potassium calcium-activated channel subfamily N member 2 | Homo sapiens |
| 6 | Because the exchange of a single residue could create a new high affinity binding site for CTX and KTX we concluded that the outer vestibule around position V342, S344, and G348 of the SK2 K+ channel pore is very similar to those of voltage-gated K+ channels such as the Shaker K+ channel, Kv1.1 and Kv1.3 channels and also to the prokaryotic KcsA channel. | ktx | potassium calcium-activated channel subfamily N member 2 | Homo sapiens |