Pub. Date : 2004 Jul
PMID : 15207092
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | [Expression of monocyte chemoattractant protein-1 in glomerular endothelial cells stimulated by high concentration of glucose]. | Glucose | C-C motif chemokine ligand 2 | Homo sapiens |
| 2 | AIM: To study the expression of monocyte chemoattractant protein-1 (MCP-1) in cultured human glomerular endothelial cells (HUGECs) stimulated by high concentration of glucose. | Glucose | C-C motif chemokine ligand 2 | Homo sapiens |
| 3 | AIM: To study the expression of monocyte chemoattractant protein-1 (MCP-1) in cultured human glomerular endothelial cells (HUGECs) stimulated by high concentration of glucose. | Glucose | C-C motif chemokine ligand 2 | Homo sapiens |
| 4 | METHODS: The effect of high concentration of glucose on the expression of MCP-1mRNA by HUGECs was detected by in situ hybridization and cell ELISA. | Glucose | C-C motif chemokine ligand 2 | Homo sapiens |
| 5 | RESULTS: The MCP-1 mRNA was only weakly expressed in HUGECs cultured under the condition of low concentration of glucose. | Glucose | C-C motif chemokine ligand 2 | Homo sapiens |
| 6 | Following a stimulation of high concentration of glucose (25 mmol/L), MCP-1 mRNA expression was upregulated from the 8th hour and reached the maximum at the 16th hour. | Glucose | C-C motif chemokine ligand 2 | Homo sapiens |
| 7 | Conditioned medium of cultured HUGECs stimulated with high concentration of glucose had marked chemotaxis for monocytes, which was inhibited by anti-MCP-1 antibody. | Glucose | C-C motif chemokine ligand 2 | Homo sapiens |
| 8 | CONCLUSION: HUGEC stimulated by high glucose may highly express MCP-1, and produce chemotatic factors for monocytes. | Glucose | C-C motif chemokine ligand 2 | Homo sapiens |