Title : Modulation of the kynurine pathway of tryptophan metabolism in search for neuroprotective agents. Focus on kynurenine-3-hydroxylase.

Pub. Date : 2003

PMID : 15206781






1 Functional Relationships(s)
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1 A novel potent and selective kynurenine-3-hydroxylase inhibitor is descibed along a preliminary evaluation in a in vivo gerbil model of its ability to increase the kynurenine and kynurenic acid concentration in both plasma and brain. Kynurenic Acid kynurenine 3-monooxygenase Homo sapiens